Archive for March, 2009

Scientists Map the Brain, Gene by Gene

Saturday, March 28th, 2009

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The human brain is surprisingly bloody. I’ve worked in neuroscience labs, and I’m used to seeing brains that are stored in glass jars filled with formaldehyde, the preserved tissue a lifeless gray. But this brain—removed from a warm body just a few hours ago—looks bruised, its folds stained purple. Blood drips from the severed stem, forming puddles on the stainless steel table.

I’m in the dissection room of the Allen Institute for Brain Science in Seattle, and the scientist next to me is in a hurry: His specimen—this fragile cortex—is falling apart. Dying, the gray matter turns acidic and begins to eat away at itself; nucleic acids unravel, cell membranes dissolve. He takes a thin, sterilized knife and slices into the tissue with disconcerting ease. I’m reminded of Jell-O and guillotines and the meat counter at the supermarket. He saws repeatedly until the brain is reduced to a series of thin slabs, which are then photographed and rushed to a freezer. All that remains is a pool of blood, like the scene of a crime.

Behind all the gore there’s a profound purpose: The scientists here are mapping the brain. And while conventional brain maps describe distinct anatomical areas, like the frontal lobes and the hippocampus—many of which were first outlined in the 19th century—the Allen Brain Atlas seeks to describe the cortex at the level of specific genes and individual neurons. Slices of tissue containing billions of brain cells will be analyzed to see which snippets of DNA are turned on in each cell.

Read the entire article here.

(Via Wired News.)

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What Can Magicians Teach Us about the Brain?

Tuesday, March 24th, 2009

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A magician tosses a ball into the air once, twice, three times. Suddenly, the ball vanishes in mid-flight. What happened?

Don’t worry, the laws of physics haven’t been broken. Magicians do not have supernatural powers; rather, they are masters of exploiting nuances of human perception, attention, and awareness. In light of this, a recent Nature Reviews Neuroscience paper, coauthored by a combination of neuroscientists (Stephen L. Macknik, Susana Martinez-Conde, both at the Barrows Neurological Institute) and magicians (Mac King, James Randi, Apollo Robbins, Teller, John Thompson), describes various ways magicians manipulate our perceptions, and proposes that these methods should inform and aid the neuroscientific study of attention and awareness.

Magicians Secrets Revealed

The underlying concept of using quirks in human perception to learn about how the mind works is an old one. Visual, auditory and multisensory illusions, in which people’s perceptions contradict the physical properties of the stimuli, have long been used by psychologists to study the mechanisms of sensory processing. Magicians use such sensory illusions in their tricks, but they also heavily use cognitive illusions, manipulating people’s attention, trains of logic and even memory. Although magicians probably haven’t studied these phenomena with the scientific method—they don’t do controlled experiments—their techniques have been tested over time, perfected by practice and performed under conditions of high scrutiny by skeptical audiences looking to spot the trick.

Read the entire article here

(Via Scientific American.)

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Brain On A Chip?

Monday, March 23rd, 2009

ScienceDaily (Mar. 23, 2009) — How does the human brain run itself without any software? Find that out, say European researchers, and a whole new field of neural computing will open up. A prototype ‘brain on a chip’ is already working.

“We know that the brain has amazing computational capabilities,” remarks Karlheinz Meier, a physicist at Heidelberg University. “Clearly there is something to learn from biology. I believe that the systems we are going to develop could form part of a new revolution in information technology.”

It’s a strong claim, but Meier is coordinating the EU-supported FACETS project which brings together scientists from 15 institutions in seven countries to do just that. Inspired by research in neuroscience, they are building a ‘neural’ computer that will work just like the brain but on a much smaller scale.

The human brain is often likened to a computer, but it differs from everyday computers in three important ways: it consumes very little power, it works well even if components fail, and it seems to work without any software.

How does it do that? Nobody yet knows, but a team within FACETS is completing an exhaustive study of brain cells – neurons – to find out exactly how they work, how they connect to each other and how the network can ‘learn’ to do new things.

Read the entire article here.

(Via Science Daily News)

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God on the brain? Scientists map religious thoughts with scans

Friday, March 13th, 2009

Jesus has been “found” in tree bark, windows and even Cheetos, but now researchers have been able to map where he – or at least religion – pops up in the brain.

Scientists report in the Proceedings of the National Academy of Sciences this week that they pinpointed where in the brain different types of religious thoughts originate. According to the study, religious musings occur in a variety of regions, confirming previous research showing there is no single “God Spot” in the brain from whence all spiritual thoughts emerge.

Study co-author Jordan Grafman, a neuroscientist at the National Institute of Neurological Disorders and Stroke at the National Institutes of Health, says that recalling a religious experience activates the same brain areas as more mundane musings, such as remembering, say, what you ate for lunch yesterday. And pondering God? Pretty much the same brain patterns as thinking about people you’ve never met such as historical figures or movie stars.

Read the entire article here.

(Via Scientific American.)

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Association Between Work Stress And Adverse Mental And Physical Health Outcomes In Police Officers

Friday, March 13th, 2009

Exposure to critical incidents, workplace discrimination, lack of cooperation among coworkers, and job dissatisfaction correlated significantly with perceived work stress among urban police officers, according to a study by researchers at Columbia University’s Mailman School of Public Health. Work stress was significantly associated with adverse outcomes, including depression and intimate partner abuse. The paper, “Mental, Physical, and Behavioral Outcomes Associated with Perceived Work Stress in Police Officers” is published in the March 2009 issue of the Journal of Criminal Justice and Behavior.

To examine the impact of a wide range of police stressors on potential health outcomes while controlling for various coping strategies in a large sample of urban police officers, the Mailman School researchers developed a five-page, 132-item survey instrument to address police stressors, perceived work stress, coping strategies, and adverse outcomes.

Read the rest of this article here

(Via Medical News Today.)

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“Mind-reading” experiment highlights how brain records memories

Thursday, March 12th, 2009

It may be possible to “read” a person’s memories just by looking at brain activity, according to research carried out by Wellcome Trust scientists. In a study published today in the journal Current Biology , they show that our memories are recorded in regular patterns, a finding which challenges current scientific thinking.

Demis Hassabis and Professor Eleanor Maguire at the Wellcome Trust Centre for Neuroimaging at UCL (University College London) have previously studied the role of a small area of the brain known as the hippocampus which is crucial for navigation, memory recall and imagining future events. Now, the researchers have shown how the hippocampus records memory.

When we move around, nerve cells (neurons) known as “place cells”, which are located in the hippocampus, activate to tell us where we are. Hassabis, Maguire and colleagues used an fMRI scanner, which measures changes in blood flow within the brain, to examine the activity of these places cells as a volunteer navigated around a virtual reality environment. The data were then analysed by a computer algorithm developed by Demis Hassabis.

“We asked whether we could see any interesting patterns in the neural activity that could tell us what the participants were thinking, or in this case where they were,” explains Professor Maguire, a Wellcome Trust Senior Research Fellow. “Surprisingly, just by looking at the brain data we could predict exactly where they were in the virtual reality environment. In other words, we could ‘read’ their spatial memories.”

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(Via EurekAlert!)

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How The Brain Responds To Stress: New And Unexpected Mechanism Identified

Wednesday, March 4th, 2009

Switching off a protein causes the brakes to fail in our natural ability to respond to stress.

Chronic stress takes a physical and emotional toll on our bodies and scientists are working on piecing together a medical puzzle to understand how we respond to stress at the cellular level in the brain. Being able to quickly and successfully respond to stress is essential for survival.

Using a rat model, Jaideep Bains, PhD, a University of Calgary scientist and his team of researchers at the Hotchkiss Brain Institute have discovered that neurons in the hypothalamus, the brain’s command centre for stress responses, interpret ‘off’ chemical signals as ‘on’ chemical signals when stress is perceived. “It’s as if the brakes in your car are now acting to speed up the vehicle, rather than slow it down.” says Bains.

This unexpected finding is being published in the March 1st online edition of Nature Neuroscience.

Want to know more about this article. Click here How The Brain Responds To Stress: New And Unexpected Mechanism Identified

(Via Medical News Today.)

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